Opioids
Isotodesnitazene
Street names: Iso, ISO
Overdose? Act now. Call emergency services — say "unresponsive, not breathing". Give naloxone for opioid-like signs. Hotlines
⚡What it does
- Euphoria, heavy sedation — nitazene-class opioid
⚠Key risks
- Fentanyl-level or greater potency
- Driving a new wave of overdose clusters since 2022
✚Overdose signs
- Pinpoint pupils
- Slow breathing
- Blue lips
📋Quick facts
Also known asIso, ISO
CategoryOpioids
Schedule / classEmerging — prosecuted as analogue (US); banned in several EU states
AppearanceWhite/yellow powder, often mixed into heroin or counterfeit pills
Street price~$30–$70/g where found
Legal statusAnalogue Act prosecutions (US); scheduled in DE/UK/others — check locally
Last updated2026-09-12
Sources: EMCDDA, DEA, NPS-AD
Category comparison — Opioids
| Substance | Class | Top risks | Street price |
|---|---|---|---|
| Isotodesnitazene | Emerging — prosecuted as analogue | Fentanyl-level or greater potency; Driving a new wave of overdose clusters since 2022 | ~$30–$70/g where found |
| Heroin | Schedule I | Extremely addictive — physical dependence in weeks; Overdose: breathing slows or stops | ~$10–$40 per bag |
| Fentanyl | Schedule II | Respiratory depression; Addiction in days | ~$20–$40 per counterfeit pill |
| Fentanyl HCl (powder) | Schedule II / analogue prosecutions | Lab-purity powder is far stronger than street mixes; Weighing errors are fatal | ~$60–$120/gram wholesale equivalent |
| Acetylfentanyl | Schedule I | ~5–15× weaker than fentanyl but still deadly at gram-level mistakes; Frequent cause of cluster overdoses | ~$25–$60/g where found |
| Furanylfentanyl (Fu-F) | Schedule I | Linked to hundreds of fatal overdoses 2016–2018; Potency similar to fentanyl | ~$20–$50/g |
Street prices are regional estimates. Potency and cuts vary constantly — see our pressed pill guide.
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Profiles are reviewed against NIDA/DEA/EMCDDA sources. See something off? Submit a correction — it goes straight to our editorial queue.